Publication record

Publications

ImStem's research team and scientific advisors have authored more than 200 peer-reviewed papers, cited over 20,000 times. The 40 publications highlighted below represent the scientific foundation of ImStem's platform, T-MSC biology and preclinical programmes, alongside seminal contributions from our founders and advisors.

Showing 40 of 40 listed publications. Each links to the publisher of record and, where indexed, to PubMed; papers in press are listed without a DOI until one is issued.

2026

Small extracellular vesicles derived from mesenchymal stem cells exert neuroprotective effect against a model of dopamine dysfunction by inhibiting caspase-8/caspase-3-mediated apoptosis

He S, et al. Journal of Integrative Neuroscience 25(6):49659.

DOI 10.31083/JIN49659 PMID 42411435
2026

Progress in process development and quality evaluation of mesenchymal cells derived from human pluripotent stem cells (人多能干细胞来源的间充质细胞的工艺开发与质量评价研究进展)

Liang Z, Pang P, Wang X, et al. Chinese Journal of Cell Biology (中国细胞生物学学报) issue 9, in press.
2026

TP53 loss elevates NF-κB–IFN-β–MHC-Ia signalling to promote NK cell resistance in osteosarcoma

Qin G, Yeung CK, Yi Y, et al. Advanced Science in press.
2026

A comparative study of mesenchymal stem cells derived from human embryonic stem cells through a trophoblast-like stage and bone marrow-derived mesenchymal stem cells in treating acute xenogeneic graft-versus-host disease in humanized mice

Wang Z, et al. Transplantation 110(8):e1649–e1656.

DOI 10.1097/TP.0000000000005781 PMID 42260632
2026

Human ES cell-derived MSC spheroids encapsulated in polydopamine nanoparticle-modified GelMA hydrogel enhance diabetic wound healing

Wu J, et al. Journal of Nanobiotechnology 24(1):129.

DOI 10.1186/s12951-026-04066-1 PMID 41634730
2026

Human–mouse chimerism for organogenesis without neural or germline contributions

Ye S, Kadier K, Yi Y, et al. International Journal of Biological Sciences in press.
2025

Pluripotent stem cell-derived mesenchymal stem cells for therapeutic applications, developmental study, and cancer research

Fu S, et al. Current Opinion in Genetics & Development 92:102327.

DOI 10.1016/j.gde.2025.102327 PMID 40054034
2025

Modeling mammalian hibernation to improve organ cold preservation: using the intestine as an example

He W, He Z, Deng W, et al. Cell Research 35(9):691–694.

DOI 10.1038/s41422-025-01149-w PMID 40721538
2025

Wound healing accelerated by stem cell bandage

Liu Y, Lv A, Wu J, et al. Chemical Engineering Journal 517:164346.

DOI 10.1016/j.cej.2025.164346
2025

Accurate delivery of mesenchymal stem cell spheroids with platelet-rich fibrin shield: enhancing survival and repair functions of Sp-MSCs in diabetic wound healing

Zhang J, et al. Advanced Science 12(25):e2413430.

DOI 10.1002/advs.202413430 PMID 40433894
2024

Chimerization of human ESC-derived extraembryonic cells with the mouse blastocyst

Fu S, et al. International Journal of Biological Sciences 20(13):5056–5069.

DOI 10.7150/ijbs.99519 PMID 39430245
2024

Mapping the global landscape for induced pluripotent stem cells from patents and clinical trials

Lyu L, Feng Y, Huang B, et al. Nature Biotechnology 42(4):563–569.

DOI 10.1038/s41587-024-02196-1 PMID 38632441
2024

Nanoghosts: harnessing mesenchymal stem cell membrane for construction of drug delivery platforms via optimized biomimetics

Xiao Y, Xu RH, Dai Y. Small 20(1):e2304824.

DOI 10.1002/smll.202304824 PMID 37653618
2023

miR-100a-5p-enriched exosomes derived from mesenchymal stem cells enhance the anti-oxidant effect in a Parkinson's disease model via regulation of Nox4/ROS/Nrf2 signaling

He S, et al. Journal of Translational Medicine 21(1):747.

DOI 10.1186/s12967-023-04638-x PMID 37875930
2023

Developmental potency of human ES cell-derived mesenchymal stem cells revealed in mouse embryos following blastocyst injection

Huang B, et al. Cell Reports 42(12):113459.

DOI 10.1016/j.celrep.2023.113459 PMID 37988266
2023

The role of T cells in Alzheimer's disease pathogenesis

Zhao J, et al. Critical Reviews in Immunology 43(6):15–23.

DOI 10.1615/CritRevImmunol.2023050145 PMID 37943150
2022

Preclinical safety evaluation and tracing of human mesenchymal stromal cell spheroids following intravenous injection into cynomolgus monkeys

Yeung CK, et al. Biomaterials 289:121759.

DOI 10.1016/j.biomaterials.2022.121759 PMID 36075143
2022

Engineering of human mesenchymal stem cells resistant to multiple natural killer subtypes

Zheng D, et al. International Journal of Biological Sciences 18(1):426–440.

DOI 10.7150/ijbs.64640 PMID 34975342
2021

Human ESC-derived MSCs enhance fat engraftment by promoting adipocyte reaggregation, secreting CCL2 and mobilizing macrophages

Borkar R, et al. Biomaterials 272:120756.

DOI 10.1016/j.biomaterials.2021.120756 PMID 33798959
2020

Embryonic stem cell-derived mesenchymal stem cells promote colon epithelial integrity and regeneration by elevating circulating IGF-1 in colitis mice

Xu J, et al. Theranostics 10(26):12204–12222.

DOI 10.7150/thno.47683 PMID 33204338
2020

Stagewise keratinocyte differentiation from human embryonic stem cells by defined signal transduction modulators

Zhong H, et al. International Journal of Biological Sciences 16(8):1450–1462.

DOI 10.7150/ijbs.44414 PMID 32210732
2019

Human ES-derived MSCs correct TNF-α-mediated alterations in a blood-brain barrier model

Ge S, et al. Fluids and Barriers of the CNS 16(1):18.

DOI 10.1186/s12987-019-0138-5 PMID 31256757
2019

Transplantation of human ESC-derived mesenchymal stem cell spheroids ameliorates spontaneous osteoarthritis in rhesus macaques

Jiang B, et al. Theranostics 9(22):6587–6600.

DOI 10.7150/thno.35391 PMID 31588237
2019

Concise review: mesenchymal stem cells derived from human pluripotent cells, an unlimited and quality-controllable source for therapeutic applications

Jiang B, et al. Stem Cells 37(5):572–581.

DOI 10.1002/stem.2964 PMID 30561809
2019

Noninvasive application of mesenchymal stem cell spheres derived from hESC accelerates wound healing in a CXCL12–CXCR4 axis-dependent manner

Wang X, et al. Theranostics 9(21):6112–6128.

DOI 10.7150/thno.32982 PMID 31534540
2018

Generation of mesenchymal stem cells from human embryonic stem cells in a complete serum-free condition

Li E, et al. International Journal of Biological Sciences 14(13):1901–1909.

DOI 10.7150/ijbs.25306 PMID 30443193
2018

Intrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model

Yan L, et al. Cell Death Discovery 4:28.

DOI 10.1038/s41420-018-0091-0 PMID 30131877
2018

Scalable generation of mesenchymal stem cells from human embryonic stem cells in 3D

Yan L, et al. International Journal of Biological Sciences 14(10):1196–1210.

DOI 10.7150/ijbs.25023 PMID 30123069
2018

Critical role of tumor necrosis factor signaling in mesenchymal stem cell-based therapy for autoimmune and inflammatory diseases

Yan L, et al. Frontiers in Immunology 9:1658.

DOI 10.3389/fimmu.2018.01658 PMID 30079066
2017

RNA editing with CRISPR-Cas13

Cox DBT, et al. Science 358(6366):1019–1027.

DOI 10.1126/science.aaq0180 PMID 29070703
2017

Spheroidal formation preserves human stem cells for prolonged time under ambient conditions for facile storage and transportation

Jiang B, et al. Biomaterials 133:275–286.

DOI 10.1016/j.biomaterials.2017.03.050 PMID 28460350
2017

Mesenchymal stem cells attenuate radiation-induced brain injury by inhibiting microglia pyroptosis

Liao H, et al. BioMed Research International 2017:1948985.

DOI 10.1155/2017/1948985 PMID 30009163
2016

Immune modulatory mesenchymal stem cells derived from human embryonic stem cells through a trophoblast-like stage

Wang X, et al. Stem Cells 34(2):380–391.

DOI 10.1002/stem.2242 PMID 26523849
2016

Concise review: one stone for multiple birds — generating universally compatible human embryonic stem cells

Zheng D, et al. Stem Cells 34(9):2269–2275.

DOI 10.1002/stem.2407 PMID 27251112
2015

Histone demethylase expression enhances human somatic cell nuclear transfer efficiency and promotes derivation of pluripotent stem cells

Chung YG, et al. Cell Stem Cell 17(6):758–766.

DOI 10.1016/j.stem.2015.10.001 PMID 26526725
2014

Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of multiple sclerosis

Wang X, et al. Stem Cell Reports 3(1):115–130.

DOI 10.1016/j.stemcr.2014.04.020 PMID 25068126
2011

Recurrent copy number variations in human induced pluripotent stem cells

Martins-Taylor K, et al. Nature Biotechnology 29(6):488–491.

DOI 10.1038/nbt.1890 PMID 21654665
2008

NANOG is a direct target of TGFβ/activin-mediated SMAD signaling in human ESCs

Xu RH, et al. Cell Stem Cell 3(2):196–206.

DOI 10.1016/j.stem.2008.07.001 PMID 18682241
2006

Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres

Chung Y, et al. Nature 439(7073):216–219.

DOI 10.1038/nature04277 PMID 16227970
2002

BMP4 initiates human embryonic stem cell differentiation to trophoblast

Xu RH, et al. Nature Biotechnology 20(12):1261–1264.

DOI 10.1038/nbt761 PMID 12426580

On this list. Bibliographic details for every entry were verified against PubMed and Crossref. The list is a curated selection, not the complete 200+ paper record of the team and its advisors; papers were chosen for direct relevance to the platform, its mechanism, its preclinical evaluation, or its intellectual foundations.